Description
Product Characteristics:
Cenexin1 is an isoform of ODF2, that unlike ODF2 is present in several somatic cell types. Cenexin1 acts as a general scaffold protein that is specifically localised to the distal/subdistal appendages of mother centrioles. Cenexin1 is required for proper localization of Plk1 to the centrosomes. This centrosomal localization of Plk1 is required for proper microtubule function. Cenexin1 recruits Plk1 via a C-terminal extension of cenexin1 that is not present in ODF2. Cenexin1 is required for proper mitotic progression, depletion of Cenexin1 µLtimately leads to chromosome missegregation and apoptosis. The ODF2 (outer dense fiber 2) gene encodes both ODF2 and Cenexin1, which have very different functions. ODF2 is a major component of sperm tail outer dense fibers (ODFs). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. They may help to maintain the passive elastic structures and elastic recoil of the sperm tail, and may also modulate sperm motility.
Subcellular location: Cytoplasm
Synonyms: sperm tail structural protein, 84 kDa outer dense fiber protein, Cenexin 1, Cenexin1 variant 1, KKT 4, KKT4, ODF 2, ODF 84, ODF2, ODF2/1, ODF2/2, ODF84, Outer dense fiber of sperm tail 2, Outer dense fiber of sperm tails 2, outer dense fiber of sperm tails, Outer dense fiber of sperm tails protein 2, Outer dense fiber of sperm tails, 84 kD, Outer dense fiber protein 2, Sperm outer dense fiber major protein 2, Testis specic autoantigen, ODFP2_HUMAN.
Target Information: The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]